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科学家发现可能导致阿尔茨海默病的新蛋白质_我的网站

一 |     阿尔茨海默病（AD）是一种使人衰弱的渐进性疾病，开始时是轻微的记忆丧失，慢慢地破坏了认知功能和记忆。    MACON, Ga. -- A South Carolina man previously convicted of smuggling protected turtles between the United States and Hong Kong faces new allegations of turtle-related crimes in Georgia. Bibb County sheriff's deputies arrested and jailed Steven Verren Baker, 43, of Holly Hill, South Carolina, on Tuesday and charged him with 15 felony counts of aggravated cruelty to animals.No lawyer was listed in Georgia court records for Baker, who remained jailed Friday with bail set at $8,250. His South Carolina lawyer has since died.Deputies were responding to a call about an abandoned dog in Macon when they noticed turtles being held in a basin nestled in a pile of trash, WMAZ-TV reports. They wrote in an incident report that a woman identified as Baker's mother told deputies that Baker had left the turtles with her about two months ago. The mother agreed to hand the turtles over to deputies, saying she had been unable to get her son to retrieve them.A veterinarian said the turtles were suffering from long-term malnutrition, bacterial and fungal infections, sepsis and shell deformities.The turtles included 11 rare albino red-eared sliders, one brown red-eared slider and two pink-bellied side necks. There was also a Chinese golden thread turtle, which is considered endangered in the wild, but is legal to breed in captivity.Baker pleaded guilty in 2018 to one count of conspiracy to smuggle wildlife in federal court in South Carolina after postal inspectors at John F. Kennedy International Airport in New York found 46 turtles concealed among noodles and candy in four packages in early 2016. The turtles would be placed in socks and shipped through the mail in boxes labeled “snacks.”Five other men pleaded guilty in the South Carolina court case, but officials described Baker as the ringleader. Federal officials say Baker was sending turtles from the United States to Hong Kong, as well as receiving turtles from Hong Kong. It's illegal to trade turtles abroad without a permit when they are protected by a treaty called the Convention on International Trade in Endangered Species of Wild Fauna and Flora.Baker served more than two years in federal prison, followed by two years of supervised release that ended in April 2022.Baker was also ordered to forfeit $263,225, which is what officials said the turtles were worth.。它目前没有治愈方法，预计到2050年将影响全球1亿多人。在美国，根据国家老龄化研究所的数据，AD是老年人痴呆的主要原因，也是第七大最常见的死亡原因。正在进行的阿尔茨海默氏症研究集中在两个关键的神经毒性蛋白上：淀粉样β（Aβ）和tau。尽管这些蛋白质已被证明与AD有关，但Aβ和tau的水平并不能持续解释或与一些疾病患者的认知能力下降的严重程度相关。作为麻省总医院布里格姆医疗系统的创始成员之一，布里格姆妇女医院的研究人员着手确定其他可能直接参与AD基本方面的蛋白质，如突触损失和神经变性。

二 | 他们将实验室的神经元暴露在大约40人的大脑提取物中，这些人要么患有AD，要么在Aβ和tau水平较高的情况下受到保护，要么在大脑中很少或没有Aβ和tau时受到保护。

三 | 科学家们发现并验证了神经节苷脂GM2激活剂（GM2A）是一种能够减少神经元发射并诱发神经元完整性丧失的蛋白质。这些蛋白质的特征可能有助于AD的病因、疾病的进展，或两者都有。高级作者、神经学系的Tracy Young-Pearse博士说："我们的数据有助于确定一种可能与阿尔茨海默病的发病机制有关的新的和潜在的重要蛋白质。有趣的是，GM2A以前被认为是一种与Tay-Sachs病非常相似的溶酶体储存障碍的致病因素，Tay-Sachs病是另一种像AD一样破坏神经元的疾病。

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Published on:07:47:29